Oocyte accumulation increases chances of pregnancy by 60%
The aim of the study was to assess whether there were differences in terms of pregnancy rates between two subgroups of women requiring Preimplantation Genetic Diagnosis (PGD): good responders to the first ovarian stimulation cycle, and women who had to repeat the cycle due to failure to produce enough oocytes per cycle for PGD. In order to be eligible for PGD, each patient must produce a minimum of 10 oocytes.
To this end, a total of 188 women with the indication of PGD and/or in vitro fertilisation (IVF) for different reasons were monitored over a four-year period (January 2011-July 2014). These reasons included a high chance of producing embryos with genetic disorders due to advanced maternal age, detection of a severe male fertility problem in the partner, repeat spontaneous abortions in previous pregnancies and/or prior embryo implantation failure. Patients were classified into two groups: the first comprised 76 women who underwent only one ovarian stimulation cycle because they responded well to treatment, and the second, 112 women with insufficient ovarian response who underwent two or three successive stimulation cycles over a 6-8 month period. In IVF, obtaining less than four oocytes per cycle is considered insufficient, vs. less than 10 eggs for PGD and IVF.
The results revealed that after two or three successive ovarian stimulation cycles, patients with a low response to hormone treatment achieved results similar to those who responded well from the outset, as no significant differences were detected between subgroups of women who underwent one, two or three ovarian stimulation cycles nor in the rate of embryo transfer which was of 59.6%, 56.8% and 60%, respectively, or the pregnancy rate per patient, which was 36.8%, 34.9%% and 31%, respectively.
This shows that oocyte accumulation is a good strategy to ensure that women who need PGD and IVF show poor response to ovarian stimulation can achieve success rates similar to the rest. The results of this study were published in the journal of Gynecological Endocrinology.
Usefulness of oocyte accumulation in low ovarian response for PGS.
Martínez F, Barbed C, Parriego M, Solé M, Rodríguez I, Coroleu B.
Gynecol Endocrinol. 2016 Feb 12:1-4, DOI:10.3109/09513590.2016.1141881