The insemination of a larger donor semen volume does not increase the success rate of this technique
Intrauterine insemination with donor semen plays a crucial role in cases of severe male infertility, and is the treatment option chosen by many homosexual female couples or women who wish to have children on their own. However, the total semen sample volume transferred may decrease depending on the type of container used to hold the sample and deposit it within the uterine walls.
A team of the Reproductive Medicine Service of Dexeus Women's Health, directed by Dr. Jorge Rodríguez-Purata, has carried out a study to determine whether incrementing the transferred semen volume from 0.2 ml (standard volume) to 0.5 ml is able to increase the live birth rate and thus the success rate of this treatment.
The study followed-up on a total of 269 assisted reproduction cycles performed using this treatment between March 2013 and April 2016. Of these cycles, 126 were included in the study group and 143 served as controls. The patient age was similar in both groups: 35.4±4.0 vs. 35.8±3.9 years. Receiver operating characteristic (ROC) curves were plotted to assess the results and explore the association between the number of live births in both groups and the semen volume used. No significant demographic differences were observed on comparing the live birth rates in the two groups. Likewise, the ROC curves revealed no correlation between the transfer of a larger donor semen volume (or greater concentration in millions per ml) and the probability of a higher live birth rate.
The authors thus conclude that the present study did not find a larger transferred semen volume to be associated to improved treatment outcomes. Patients therefore should be informed that the standard donor semen volume is considered adequate for obtaining optimum results with this treatment.
Inseminated volume 0.2 ml vs. 0.5 ml in donor intrauterine insemination (dIUI) cycles: A randomized
Rodriguez-Purata J1, Laura L1, Gonzalez C1, Ballester M1, Rodriguez I1, Martinez F1, Barri PN1, Coroleu B1
Reproductive Medicine Service. Dexeus University Hospital. Barcelona, Spain
See scientific poster (PDF)